In regard to nuclear proliferation and arms control, the fundamental problem is clear: Either we begin finding creative, outside-the-box solutions or the international nuclear safeguards regime will become obsolete.
For this reason, I have been calling for new approaches in a number of areas. First, a recommitment to disarmament -- a move away from national security strategies that rely on nuclear weapons, which serve as a constant stimulus for other nations to acquire them. Second, tightened controls on the proliferation-sensitive parts of the nuclear fuel cycle. By bringing multinational control to any operation that enriches uranium or separates plutonium, we can lower the risk of these materials being diverted to weapons. A parallel step would be to create a mechanism to ensure a reliable supply of reactor fuel to bona fide users, including a fuel bank under control of the International Atomic Energy Agency.
The third area has been more problematic: how to deal creatively with the three countries that remain outside the nuclear Non-Proliferation Treaty (NPT): Pakistan and India, both holders of nuclear arsenals, and Israel, which maintains an official policy of ambiguity but is believed to be nuclear-weapons-capable. However fervently we might wish it, none of these three is likely to give up its nuclear weapons or the nuclear weapons option outside of a global or regional arms control framework. Our traditional strategy -- of treating such states as outsiders -- is no longer a realistic method of bringing these last few countries into the fold.